Crystal structure of the human T cell receptor CD3 heterodimer complexed to the therapeutic mAb OKT3
نویسندگان
چکیده
The CD3 heterodimer is essential for expression and function of the T cell receptor. The crystal structure of the human CD3 heterodimer is described to 2.1-Å resolution complexed with OKT3, a therapeutic mAb that not only activates and tolerizes mature T cells but also induces regulatory T cells. The mode of CD3 dimerization provides a general structural basis for CD3 assembly and maps candidate T cell antigen receptor docking sites, including a duplicated linear region rich in acidic residues that is unique to human CD3 . OKT3 binds to an atypically small area of CD3 and has a low affinity for the isolated CD3 heterodimer. The structure of the OKT3 CD3 complex has implications for T cell signaling and therapeutic design.
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